ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.
Identifieur interne : 002354 ( Main/Exploration ); précédent : 002353; suivant : 002355ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.
Auteurs : Bruno Vergès [Finlande] ; Martin Adiels [Finlande] ; Jan Boren [Finlande] ; Peter Hugh Barrett [Finlande] ; Gerald F. Watts [Finlande] ; Dick Chan [Finlande] ; Laurence Duvillard [Finlande] ; Sanni Söderlund [Finlande] ; Niina Matikainen [Finlande] ; Juhani Kahri [Finlande] ; Nina Lundbom [Finlande] ; Jesper Lundbom [Finlande] ; Antti Hakkarainen [Finlande] ; Serge Aho [Finlande] ; Isabelle Simoneau-Robin [Finlande] ; Marja-Riitta Taskinen [Finlande]Source :
- The Journal of clinical endocrinology and metabolism [ 1945-7197 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Apolipoprotéine A-II (métabolisme), Cinétique, Femelle, Humains, Insulinorésistance, Lipoprotéines HDL (métabolisme), Lipoprotéines VLDL (métabolisme), Mâle, Obésité abdominale (), Sujet âgé, Syndrome métabolique X (anatomopathologie), Syndrome métabolique X (métabolisme), Syndrome métabolique X (étiologie).
- MESH :
- anatomopathologie : Syndrome métabolique X.
- métabolisme : Apolipoprotéine A-II, Lipoprotéines HDL, Lipoprotéines VLDL, Syndrome métabolique X.
- étiologie : Syndrome métabolique X.
- Adulte, Adulte d'âge moyen, Cinétique, Femelle, Humains, Insulinorésistance, Mâle, Obésité abdominale, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Apolipoprotein A-II (metabolism), Female, Humans, Insulin Resistance, Kinetics, Lipoproteins, HDL (metabolism), Lipoproteins, VLDL (metabolism), Male, Metabolic Syndrome X (etiology), Metabolic Syndrome X (metabolism), Metabolic Syndrome X (pathology), Middle Aged, Obesity, Abdominal (complications).
- MESH :
- chemical , metabolism : Apolipoprotein A-II, Lipoproteins, HDL, Lipoproteins, VLDL.
- complications : Obesity, Abdominal.
- etiology : Metabolic Syndrome X.
- metabolism : Metabolic Syndrome X.
- pathology : Metabolic Syndrome X.
- Adult, Aged, Female, Humans, Insulin Resistance, Kinetics, Male, Middle Aged.
Abstract
We study the associations between apoA-II fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and apoA-I and show that, in abdominally obese individuals, apoA-II FCR is positively and independently associated with both apoA-I FCR and VLDL1-TG indirect FCR.
DOI: 10.1210/jc.2015-3740
PubMed: 26835543
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.</title><author><name sortKey="Verges, Bruno" sort="Verges, Bruno" uniqKey="Verges B" first="Bruno" last="Vergès">Bruno Vergès</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Adiels, Martin" sort="Adiels, Martin" uniqKey="Adiels M" first="Martin" last="Adiels">Martin Adiels</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Boren">Jan Boren</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Barrett, Peter Hugh" sort="Barrett, Peter Hugh" uniqKey="Barrett P" first="Peter Hugh" last="Barrett">Peter Hugh Barrett</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F" last="Watts">Gerald F. Watts</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Dick" sort="Chan, Dick" uniqKey="Chan D" first="Dick" last="Chan">Dick Chan</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Duvillard, Laurence" sort="Duvillard, Laurence" uniqKey="Duvillard L" first="Laurence" last="Duvillard">Laurence Duvillard</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Soderlund, Sanni" sort="Soderlund, Sanni" uniqKey="Soderlund S" first="Sanni" last="Söderlund">Sanni Söderlund</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Matikainen, Niina" sort="Matikainen, Niina" uniqKey="Matikainen N" first="Niina" last="Matikainen">Niina Matikainen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kahri, Juhani" sort="Kahri, Juhani" uniqKey="Kahri J" first="Juhani" last="Kahri">Juhani Kahri</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lundbom, Nina" sort="Lundbom, Nina" uniqKey="Lundbom N" first="Nina" last="Lundbom">Nina Lundbom</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lundbom, Jesper" sort="Lundbom, Jesper" uniqKey="Lundbom J" first="Jesper" last="Lundbom">Jesper Lundbom</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hakkarainen, Antti" sort="Hakkarainen, Antti" uniqKey="Hakkarainen A" first="Antti" last="Hakkarainen">Antti Hakkarainen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Aho, Serge" sort="Aho, Serge" uniqKey="Aho S" first="Serge" last="Aho">Serge Aho</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Simoneau Robin, Isabelle" sort="Simoneau Robin, Isabelle" uniqKey="Simoneau Robin I" first="Isabelle" last="Simoneau-Robin">Isabelle Simoneau-Robin</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Taskinen, Marja Riitta" sort="Taskinen, Marja Riitta" uniqKey="Taskinen M" first="Marja-Riitta" last="Taskinen">Marja-Riitta Taskinen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26835543</idno><idno type="pmid">26835543</idno><idno type="doi">10.1210/jc.2015-3740</idno><idno type="wicri:Area/PubMed/Corpus">002002</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002002</idno><idno type="wicri:Area/PubMed/Curation">001F77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F77</idno><idno type="wicri:Area/PubMed/Checkpoint">001F77</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F77</idno><idno type="wicri:Area/Ncbi/Merge">003090</idno><idno type="wicri:Area/Ncbi/Curation">003090</idno><idno type="wicri:Area/Ncbi/Checkpoint">003090</idno><idno type="wicri:Area/Main/Merge">002353</idno><idno type="wicri:Area/Main/Curation">002354</idno><idno type="wicri:Area/Main/Exploration">002354</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.</title><author><name sortKey="Verges, Bruno" sort="Verges, Bruno" uniqKey="Verges B" first="Bruno" last="Vergès">Bruno Vergès</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Adiels, Martin" sort="Adiels, Martin" uniqKey="Adiels M" first="Martin" last="Adiels">Martin Adiels</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Boren">Jan Boren</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Barrett, Peter Hugh" sort="Barrett, Peter Hugh" uniqKey="Barrett P" first="Peter Hugh" last="Barrett">Peter Hugh Barrett</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F" last="Watts">Gerald F. Watts</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Dick" sort="Chan, Dick" uniqKey="Chan D" first="Dick" last="Chan">Dick Chan</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Duvillard, Laurence" sort="Duvillard, Laurence" uniqKey="Duvillard L" first="Laurence" last="Duvillard">Laurence Duvillard</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Soderlund, Sanni" sort="Soderlund, Sanni" uniqKey="Soderlund S" first="Sanni" last="Söderlund">Sanni Söderlund</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Matikainen, Niina" sort="Matikainen, Niina" uniqKey="Matikainen N" first="Niina" last="Matikainen">Niina Matikainen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kahri, Juhani" sort="Kahri, Juhani" uniqKey="Kahri J" first="Juhani" last="Kahri">Juhani Kahri</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lundbom, Nina" sort="Lundbom, Nina" uniqKey="Lundbom N" first="Nina" last="Lundbom">Nina Lundbom</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lundbom, Jesper" sort="Lundbom, Jesper" uniqKey="Lundbom J" first="Jesper" last="Lundbom">Jesper Lundbom</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Hakkarainen, Antti" sort="Hakkarainen, Antti" uniqKey="Hakkarainen A" first="Antti" last="Hakkarainen">Antti Hakkarainen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Aho, Serge" sort="Aho, Serge" uniqKey="Aho S" first="Serge" last="Aho">Serge Aho</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Simoneau Robin, Isabelle" sort="Simoneau Robin, Isabelle" uniqKey="Simoneau Robin I" first="Isabelle" last="Simoneau-Robin">Isabelle Simoneau-Robin</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Taskinen, Marja Riitta" sort="Taskinen, Marja Riitta" uniqKey="Taskinen M" first="Marja-Riitta" last="Taskinen">Marja-Riitta Taskinen</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Departments of Endocrinology-Diabetology (B.V., I.S.-R.), Medical Biology (L.D.), and Statistics and Epidemiology (S.A.), University Hospital, 21000 Dijon, France; Centre Recherche INSERM 866 (B.V., L.D.), 21079 Dijon, France; Departments of Molecular and Clinical Medicine (M.A., J.B.) and Mathematical Sciences (M.A.), University of Gothenburg, S-405 30 Gothenburg, Sweden; Faculty of Engineering, Computing, and Mathematics (P.H.B.), University of Western Australia, Perth, Western Australia 6872, Australia; Lipid Disorders Clinic (G.F.W., D.C.), Metabolic Research Centre, Department of Cardiovascular Medicine, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6847, Australia; and Heart and Lung Centre (S.S., N.M., M.-R.T.), Helsinki University Hospital and Research Programs' Unit, Department of Diabetes and Obesity, University of Helsinki, Endocrinology, Abdominal Centre (N.M.), Department of Internal Medicine and Rehabilitation (J.K.), and Department of Radiology (N.L., J.L., A.H.), Helsingin ja Uudenmaan Sairaanhoitopiiri Medical Imaging Centre, Helsinki University Hospital, FI-00290 Helsinki</wicri:regionArea><wicri:noRegion>FI-00290 Helsinki</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of clinical endocrinology and metabolism</title><idno type="eISSN">1945-7197</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Apolipoprotein A-II (metabolism)</term><term>Female</term><term>Humans</term><term>Insulin Resistance</term><term>Kinetics</term><term>Lipoproteins, HDL (metabolism)</term><term>Lipoproteins, VLDL (metabolism)</term><term>Male</term><term>Metabolic Syndrome X (etiology)</term><term>Metabolic Syndrome X (metabolism)</term><term>Metabolic Syndrome X (pathology)</term><term>Middle Aged</term><term>Obesity, Abdominal (complications)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Apolipoprotéine A-II (métabolisme)</term><term>Cinétique</term><term>Femelle</term><term>Humains</term><term>Insulinorésistance</term><term>Lipoprotéines HDL (métabolisme)</term><term>Lipoprotéines VLDL (métabolisme)</term><term>Mâle</term><term>Obésité abdominale ()</term><term>Sujet âgé</term><term>Syndrome métabolique X (anatomopathologie)</term><term>Syndrome métabolique X (métabolisme)</term><term>Syndrome métabolique X (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apolipoprotein A-II</term><term>Lipoproteins, HDL</term><term>Lipoproteins, VLDL</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Syndrome métabolique X</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obesity, Abdominal</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Apolipoprotéine A-II</term><term>Lipoprotéines HDL</term><term>Lipoprotéines VLDL</term><term>Syndrome métabolique X</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Syndrome métabolique X</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Insulin Resistance</term><term>Kinetics</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cinétique</term><term>Femelle</term><term>Humains</term><term>Insulinorésistance</term><term>Mâle</term><term>Obésité abdominale</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We study the associations between apoA-II fractional catabolic rate (FCR) and the kinetics of VLDL subspecies and apoA-I and show that, in abdominally obese individuals, apoA-II FCR is positively and independently associated with both apoA-I FCR and VLDL1-TG indirect FCR.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Verges, Bruno" sort="Verges, Bruno" uniqKey="Verges B" first="Bruno" last="Vergès">Bruno Vergès</name></noRegion><name sortKey="Adiels, Martin" sort="Adiels, Martin" uniqKey="Adiels M" first="Martin" last="Adiels">Martin Adiels</name><name sortKey="Aho, Serge" sort="Aho, Serge" uniqKey="Aho S" first="Serge" last="Aho">Serge Aho</name><name sortKey="Barrett, Peter Hugh" sort="Barrett, Peter Hugh" uniqKey="Barrett P" first="Peter Hugh" last="Barrett">Peter Hugh Barrett</name><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Boren">Jan Boren</name><name sortKey="Chan, Dick" sort="Chan, Dick" uniqKey="Chan D" first="Dick" last="Chan">Dick Chan</name><name sortKey="Duvillard, Laurence" sort="Duvillard, Laurence" uniqKey="Duvillard L" first="Laurence" last="Duvillard">Laurence Duvillard</name><name sortKey="Hakkarainen, Antti" sort="Hakkarainen, Antti" uniqKey="Hakkarainen A" first="Antti" last="Hakkarainen">Antti Hakkarainen</name><name sortKey="Kahri, Juhani" sort="Kahri, Juhani" uniqKey="Kahri J" first="Juhani" last="Kahri">Juhani Kahri</name><name sortKey="Lundbom, Jesper" sort="Lundbom, Jesper" uniqKey="Lundbom J" first="Jesper" last="Lundbom">Jesper Lundbom</name><name sortKey="Lundbom, Nina" sort="Lundbom, Nina" uniqKey="Lundbom N" first="Nina" last="Lundbom">Nina Lundbom</name><name sortKey="Matikainen, Niina" sort="Matikainen, Niina" uniqKey="Matikainen N" first="Niina" last="Matikainen">Niina Matikainen</name><name sortKey="Simoneau Robin, Isabelle" sort="Simoneau Robin, Isabelle" uniqKey="Simoneau Robin I" first="Isabelle" last="Simoneau-Robin">Isabelle Simoneau-Robin</name><name sortKey="Soderlund, Sanni" sort="Soderlund, Sanni" uniqKey="Soderlund S" first="Sanni" last="Söderlund">Sanni Söderlund</name><name sortKey="Taskinen, Marja Riitta" sort="Taskinen, Marja Riitta" uniqKey="Taskinen M" first="Marja-Riitta" last="Taskinen">Marja-Riitta Taskinen</name><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F" last="Watts">Gerald F. Watts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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